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found that supplementation with folic acid (the synthetic form) in girls with Down syndrome may not be as effective as the active form

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From a molecular viewpoint, key mechanistic themes have emerged: microbial metabolites such as SCFAs, tryptophan metabolites, and bile acids can penetrate into the CNS or signal via the vagus, modulating microglial activation, astrocytic support, and even neuronal gene expression

Yes, although Vitamin B12 is generally safe, some peopleespecially when taking high doses or injectionsreport side effects like anxiety, insomnia, acne, or palpitations